Though we are bombarded with the positive medical attributes of marijuana, why does resistance of legalization exist?

Below are 4 common ways to compose a Thesis Statement. Read each Thesis, they all are examples for the same topic. The instructions to follow are at the end.
1. Question
Though we are bombarded with the positive medical attributes of marijuana, why does resistance of legalization exist?
2. Fact
World renown scientists have concluded through various studies that marijuana contains healing attributes but like all drug classifications, there is a need for regulation and oversight.
3. Statement
Its not man made so its good for us. Everyone knows when mankind begin to intervene, things become less effective with all kinds of side effects like leaking bowels.
4. Quote
“Moderation is the key with consuming anything. But I have never heard of any individual overdosing on the green stuff” (Smith 12)
*Pick any topic and provide 4 different Thesis Statements as I have done above for the topic “Marijuana”*